منابع مشابه
Asthma phenotypes and endotypes: a personalized approach to treatment.
PURPOSE OF REVIEW Asthma is quite common and is better described as a syndrome with a heterogeneous presentation than as a single disease. Although most individuals can be effectively managed using a guideline-directed approach to care, those with the most severe illness may benefit from a more targeted therapy. The review describes our current understanding of how asthma phenotypes (observable...
متن کاملAsthma phenotypes and endotypes: an evolving paradigm for classification.
Asthma is a common chronic disease characterized by intermittent chest symptoms, variable airways obstruction, and bronchial hyperresponsiveness. Research performed over the past one to two decades has sought to better understand the heterogeneous clinical nature of asthma. Whereas older attempts at phenotyping asthma emphasized the duality of allergic vs. non-allergic asthma, more recent non-b...
متن کاملPhenotypes and endotypes of severe asthma in children
Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identifica...
متن کاملEndotypes of Asthma in Children
Asthma is a syndrome that includes several disease variants. Definition of asthma is a chronic disorder of the lung with variable airway obstruction, wheeze/cough, and an underlying inflammatory process with remodeling. It appears that atopic genes are not necessarily directly related to childhood asthma. Airway epithelial cells express genes that encode proteins directly related to asthma. Mat...
متن کاملAsthma Endotypes and an Overview of Targeted Therapy for Asthma
Guidelines for the management of severe asthma do not emphasize the measurement of the inflammatory component of airway disease to indicate appropriate treatments or to monitor response to treatment. Inflammation is a central component of asthma and contributes to symptoms, physiological, and structural abnormalities. It can be assessed by a number of endotyping strategies based on "omics" tech...
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ژورنال
عنوان ژورنال: Allergy
سال: 2012
ISSN: 0105-4538
DOI: 10.1111/j.1398-9995.2012.02832.x